Focused sprint · Fixed scope · 10-day delivery

Build a better variant library before your next screen.

Foldry.bio helps enzyme engineering teams turn sequence and assay constraints into ranked candidates, constrained libraries, risk flags, and handoff-ready outputs for the next build-test round. Best suited for programs with a lead enzyme, a defined optimization objective, and a real path to test shortlisted variants.

Send your enzyme brief→See sample output
Designed for lead-enzyme optimizationSample outputs available on requestNDA available before technical discussion

Common friction

✕Plate budget disappears into near-duplicate variants
✕Random or intuition-led choices dominate the shortlist
✕Too much time goes into tooling and literature before the next experiment
✕The team cannot explain why each candidate made the plate
✕Assay results do not feed back cleanly into the next design round

The design pack

A focused deliverable your wet lab can use immediately.

The offer stays intentionally narrow: one lead enzyme, one concrete optimization objective, and a fixed-scope sprint that results in a clear next plate.

⚗️

Ranked Mutation Candidates

Prioritized with multiple scoring signals, your assay constraints, and explicit do-not-mutate boundaries.

🧪

96-Well Core Library

A compact set of conservative, diverse candidates for teams working within a tight screening budget.

🔬

384-Well Expanded Library

Broader coverage for teams that want more exploration while keeping the shortlist interpretable.

⚠️

Risk Flag Report

Potential stability, expression, and design-space risks surfaced before the next build-test round.

📦

Handoff Files

CSV, FASTA, and structured outputs formatted for synthesis vendors or internal wet-lab workflows.

🔄

Round-2 Learning Loop

Once assay results are available, they can be folded back into the next prioritization so each round becomes more informed.

Why Foldry.bio

Technical prioritization built for real build-test cycles.

Foldry.bio is built for teams that need a clearer next experiment: ranked candidates, constrained library design, explicit risk notes, and outputs that can move directly into a wet-lab workflow.

Technical focus

Sequence and structure-informed candidate prioritization, constraint-aware library design, and outputs that a wet-lab team can use without reformatting.

Decision continuity

Scoping, technical review, and delivery stay in one thread, so constraints, trade-offs, and next-step decisions do not get lost across handoffs.

Two-stage design engine

A constrained first-round library, then a smarter second round.

Foldry.bio is designed around two stages: first, generate and prioritize a compact, testable library under real assay and screening constraints; then use measured outcomes to refine scoring and narrow the next round.

The initial sprint covers Stage 1 only. Stage 2 begins once assay measurements are available.

Stage 1

Initial candidate generation and library design

  • Generate and rank candidates under assay and library constraints.
  • Combine objective rules, allowed or forbidden positions, and multiple scoring signals.
  • Deliver a compact first-round library with rationale and risk flags.

Stage 2

Assay-informed round-2 optimization

  • Ingest first-round assay measurements and observed hits or misses.
  • Update prioritization using project-specific signals and revised hypotheses.
  • Propose a more informed round-2 shortlist.

What you actually receive

Concrete outputs, not generic AI claims.

This is the format of the output clients receive: a ranked shortlist, candidate-level rationale, and explicit distinctions between core-library picks and higher-risk exploration candidates.

Illustrative example output format

VariantObjectiveScoring signalsRecommendation
A172V / T208IThermostabilityConsensus + burial + diversityCore-library candidate
L91F / E155QSolvent toleranceConstraint-safe + motif awareGood assay fit
R63K / N248DExpressionSequence prior + risk-balancedExpanded-library candidate

Example rationale

“Kept in the core library because it preserves catalytic-site constraints, broadens sequence diversity, and scores well on the selected objective without compounding obvious liabilities.”

Example risk flag

“Interesting for the expanded library, but marked as higher expression risk and less suitable for a tight first plate unless assay capacity improves.”

Benchmark note

Foldry.bio does not claim guaranteed wet-lab success from a single sprint. The goal is a more plausible, better-documented shortlist than unguided selection. Additional illustrative samples can be shared during fit discussions.

Fit boundaries

Better qualification makes the service more credible.

Good fit

  • ✓You already have a lead enzyme or a starting variant family.
  • ✓You know the property you want to improve and how you will measure it.
  • ✓You can test shortlisted variants experimentally after the sprint.
  • ✓You want better prioritization before committing the next 96- or 384-well plate.

Not a fit

  • ✕Open-ended discovery without a starting enzyme.
  • ✕Guaranteed-outcome expectations for a single round.
  • ✕Fully outsourced large-scale campaigns from day one.
  • ✕Buyers looking for self-serve software instead of a scoped technical service.

Pricing

Fixed-scope first engagement, flexible after that.

Pricing depends on fit, scope, and target complexity.

Discovery review

Free

Brief fit check and scope review

  • ✓Lead-enzyme fit assessment
  • ✓Constraint and assay review
  • ✓Timeline confirmation
Best starting point

Pilot sprint

Starting at $3,500

Fixed-scope 10-day delivery

  • ✓Ranked candidates and library design
  • ✓Core and expanded shortlist options
  • ✓Risk review and handoff files
  • ✓Round-2 follow-up framing

Ongoing support

Custom

For multi-round campaigns after initial fit

  • ✓Multi-round prioritization
  • ✓Assay feedback integration
  • ✓NDA and custom scope support

FAQ

The questions technical buyers usually ask first.

Do you need prior assay data?

No. A lead enzyme, a concrete property objective, and a realistic test plan are enough to scope an initial sprint.

Do you need a structure?

Not always. Foldry.bio can start from sequence plus assay context and incorporate structural information when it is available and useful.

What do you need from us to start?

A brief with the lead enzyme or variant family, the property to improve, the assay context, the plate budget, and any hard constraints is enough for an initial fit review.

What happens in 10 days?

The sprint covers brief review, candidate prioritization, library construction, risk review, and handoff-ready outputs for the wet lab.

Do you guarantee improved variants in one round?

No. The service is designed to improve prioritization quality and reduce low-information picks, not to promise a single-round outcome.

How do you handle confidentiality and sequence data?

Projects can start under NDA. A lightweight fit conversation can happen before sensitive technical details are shared, and the first email does not need to include proprietary sequence information if you prefer not to send it yet.

Start the conversation

Send the brief you already have.

If it looks like a fit, the next step is a scoped conversation.

Include these in the email

  • 1.Lead enzyme or current starting variant.
  • 2.Property to improve and the assay context you care about.
  • 3.Plate budget, timeline, and any hard constraints.
Email hello@foldry.bio→

NDA available before sharing sensitive technical details.